The Role of Donor-Specific HLA Alloantibodies in Liver Transplantation
Identifieur interne : 000E57 ( Main/Exploration ); précédent : 000E56; suivant : 000E58The Role of Donor-Specific HLA Alloantibodies in Liver Transplantation
Auteurs : J. G. O Eary [États-Unis] ; A. J. Demetris [États-Unis] ; L. S. Friedman [États-Unis] ; H. M. Gebel [États-Unis] ; P. F. Halloran [Canada] ; A. D. Kirk [États-Unis] ; S. J. Knechtle [États-Unis] ; S. V. Mcdiarmid [États-Unis] ; A. Shaked [États-Unis] ; P. I. Terasaki [États-Unis] ; K. J. Tinckam [Canada] ; S. J. Tomlanovich [États-Unis] ; K. J. Wood [Royaume-Uni] ; E. S. Woodle [États-Unis] ; A. A. Zachary [États-Unis] ; G. B. Klintmalm [États-Unis]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6135 ] ; 2014.
Abstract
The impact of donor-specific HLA alloantibodies (DSA) on short- and long-term liver transplant outcome is not clearly defined. While it is clear that not all levels of allosensitization produce overt clinical injury, and that liver allografts possess some degree of alloantibody resistance, alloantibody-mediated adverse consequences are increasingly being recognized. To better define the current state of this topic, we assembled experts to provide insights, explore controversies and develop recommendations for future research on the consequences of DSA in liver transplantation. This article summarizes the proceedings of this inaugural meeting.
Several insights emerged. Acute antibody-mediated rejection (AMR), although rarely diagnosed, is increasingly understood to overlap with T cell–mediated rejection. Isolated liver allograft recipients are at increased risk of early allograft immunologic injury when preformed DSA are high titer and persist posttransplantation. Persons who undergo simultaneous liver–kidney transplantation are at risk of renal AMR when Class II DSA persist posttransplantation. Other under-appreciated DSA associations include ductopenia and fibrosis, plasma cell hepatitis, biliary strictures and accelerated fibrosis associated with recurrent liver disease. Standardized DSA testing and diagnostic criteria for both acute and chronic AMR are needed to distil existing associations into etiological processes in order to develop responsive therapeutic strategies.
Url:
DOI: 10.1111/ajt.12667
PubMed: 24580828
PubMed Central: 4412601
Affiliations:
- Canada, Royaume-Uni, États-Unis
- Angleterre, Californie, Géorgie (États-Unis), Maryland, Massachusetts, Ohio, Oxfordshire, Pennsylvanie, Texas
- Oxford
- Université d'Oxford
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Le document en format XML
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Kirk</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Surgery, Emory University, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Surgery, Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Knechtle, S J" sort="Knechtle, S J" uniqKey="Knechtle S" first="S. J." last="Knechtle">S. J. Knechtle</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Surgery, Emory University, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Surgery, Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Mcdiarmid, S V" sort="Mcdiarmid, S V" uniqKey="Mcdiarmid S" first="S. V." last="Mcdiarmid">S. V. 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G." last="O Eary">J. G. O Eary</name><affiliation wicri:level="2"><nlm:aff id="A1">Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Demetris, A J" sort="Demetris, A J" uniqKey="Demetris A" first="A. J." last="Demetris">A. J. Demetris</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Friedman, L S" sort="Friedman, L S" uniqKey="Friedman L" first="L. S." last="Friedman">L. S. Friedman</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, Newton-Wellesley Hospital, Newton, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Medicine, Newton-Wellesley Hospital, Newton</wicri:cityArea></affiliation></author><author><name sortKey="Gebel, H M" sort="Gebel, H M" uniqKey="Gebel H" first="H. M." last="Gebel">H. M. Gebel</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Halloran, P F" sort="Halloran, P F" uniqKey="Halloran P" first="P. F." last="Halloran">P. F. Halloran</name><affiliation wicri:level="1"><nlm:aff id="A5">Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Kirk, A D" sort="Kirk, A D" uniqKey="Kirk A" first="A. D." last="Kirk">A. D. Kirk</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Surgery, Emory University, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Surgery, Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Knechtle, S J" sort="Knechtle, S J" uniqKey="Knechtle S" first="S. J." last="Knechtle">S. J. Knechtle</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Surgery, Emory University, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Surgery, Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Mcdiarmid, S V" sort="Mcdiarmid, S V" uniqKey="Mcdiarmid S" first="S. V." last="Mcdiarmid">S. V. Mcdiarmid</name><affiliation wicri:level="2"><nlm:aff id="A7">Pediatric Transplantation, University of California, Los Angeles, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pediatric Transplantation, University of California, Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Shaked, A" sort="Shaked, A" uniqKey="Shaked A" first="A." last="Shaked">A. Shaked</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Terasaki, P I" sort="Terasaki, P I" uniqKey="Terasaki P" first="P. I." last="Terasaki">P. I. Terasaki</name><affiliation wicri:level="2"><nlm:aff id="A9">Terasaki Foundation Laboratory, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Terasaki Foundation Laboratory, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Tinckam, K J" sort="Tinckam, K J" uniqKey="Tinckam K" first="K. J." last="Tinckam">K. J. Tinckam</name><affiliation wicri:level="1"><nlm:aff id="A10">Histocompatibility Laboratory, University Health Network, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Histocompatibility Laboratory, University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Tomlanovich, S J" sort="Tomlanovich, S J" uniqKey="Tomlanovich S" first="S. J." last="Tomlanovich">S. J. Tomlanovich</name><affiliation wicri:level="2"><nlm:aff id="A11">Pancreas Transplant Services, University of California, San Francisco, San Francisco, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pancreas Transplant Services, University of California, San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Wood, K J" sort="Wood, K J" uniqKey="Wood K" first="K. J." last="Wood">K. J. Wood</name><affiliation wicri:level="4"><nlm:aff id="A12">Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Surgical Sciences, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Woodle, E S" sort="Woodle, E S" uniqKey="Woodle E" first="E. S." last="Woodle">E. S. Woodle</name><affiliation wicri:level="2"><nlm:aff id="A13">Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Surgery, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Zachary, A A" sort="Zachary, A A" uniqKey="Zachary A" first="A. A." last="Zachary">A. A. Zachary</name><affiliation wicri:level="2"><nlm:aff id="A14">Immunogenetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Immunogenetics Laboratory, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Klintmalm, G B" sort="Klintmalm, G B" uniqKey="Klintmalm G" first="G. B." last="Klintmalm">G. B. Klintmalm</name><affiliation wicri:level="2"><nlm:aff id="A1">Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas</wicri:cityArea></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="ISSN">1600-6135</idno><idno type="eISSN">1600-6143</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The impact of donor-specific HLA alloantibodies (DSA) on short- and long-term liver transplant outcome is not clearly defined. While it is clear that not all levels of allosensitization produce overt clinical injury, and that liver allografts possess some degree of alloantibody resistance, alloantibody-mediated adverse consequences are increasingly being recognized. To better define the current state of this topic, we assembled experts to provide insights, explore controversies and develop recommendations for future research on the consequences of DSA in liver transplantation. This article summarizes the proceedings of this inaugural meeting.</p><p id="P2">Several insights emerged. Acute antibody-mediated rejection (AMR), although rarely diagnosed, is increasingly understood to overlap with T cell–mediated rejection. Isolated liver allograft recipients are at increased risk of early allograft immunologic injury when preformed DSA are high titer and persist posttransplantation. Persons who undergo simultaneous liver–kidney transplantation are at risk of renal AMR when Class II DSA persist posttransplantation. Other under-appreciated DSA associations include ductopenia and fibrosis, plasma cell hepatitis, biliary strictures and accelerated fibrosis associated with recurrent liver disease. Standardized DSA testing and diagnostic criteria for both acute and chronic AMR are needed to distil existing associations into etiological processes in order to develop responsive therapeutic strategies.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Massachusetts</li><li>Ohio</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Texas</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="O Eary, J G" sort="O Eary, J G" uniqKey="O Eary J" first="J. G." last="O Eary">J. G. O Eary</name></region><name sortKey="Demetris, A J" sort="Demetris, A J" uniqKey="Demetris A" first="A. J." last="Demetris">A. J. Demetris</name><name sortKey="Friedman, L S" sort="Friedman, L S" uniqKey="Friedman L" first="L. S." last="Friedman">L. S. Friedman</name><name sortKey="Gebel, H M" sort="Gebel, H M" uniqKey="Gebel H" first="H. M." last="Gebel">H. M. Gebel</name><name sortKey="Kirk, A D" sort="Kirk, A D" uniqKey="Kirk A" first="A. D." last="Kirk">A. D. Kirk</name><name sortKey="Klintmalm, G B" sort="Klintmalm, G B" uniqKey="Klintmalm G" first="G. B." last="Klintmalm">G. B. Klintmalm</name><name sortKey="Knechtle, S J" sort="Knechtle, S J" uniqKey="Knechtle S" first="S. J." last="Knechtle">S. J. Knechtle</name><name sortKey="Mcdiarmid, S V" sort="Mcdiarmid, S V" uniqKey="Mcdiarmid S" first="S. V." last="Mcdiarmid">S. V. Mcdiarmid</name><name sortKey="Shaked, A" sort="Shaked, A" uniqKey="Shaked A" first="A." last="Shaked">A. Shaked</name><name sortKey="Terasaki, P I" sort="Terasaki, P I" uniqKey="Terasaki P" first="P. I." last="Terasaki">P. I. Terasaki</name><name sortKey="Tomlanovich, S J" sort="Tomlanovich, S J" uniqKey="Tomlanovich S" first="S. J." last="Tomlanovich">S. J. Tomlanovich</name><name sortKey="Woodle, E S" sort="Woodle, E S" uniqKey="Woodle E" first="E. S." last="Woodle">E. S. Woodle</name><name sortKey="Zachary, A A" sort="Zachary, A A" uniqKey="Zachary A" first="A. A." last="Zachary">A. A. Zachary</name></country><country name="Canada"><noRegion><name sortKey="Halloran, P F" sort="Halloran, P F" uniqKey="Halloran P" first="P. F." last="Halloran">P. F. Halloran</name></noRegion><name sortKey="Tinckam, K J" sort="Tinckam, K J" uniqKey="Tinckam K" first="K. J." last="Tinckam">K. J. Tinckam</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Wood, K J" sort="Wood, K J" uniqKey="Wood K" first="K. J." last="Wood">K. J. Wood</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= PMC:4412601
|texte= The Role of Donor-Specific HLA Alloantibodies in Liver Transplantation
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24580828" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |